ea0092op-05-03 | Oral Session 5: Young Investigators / Basic | ETA2023
Hoen Esmee
, Goossens Franka
, Falize Kim
, Mayerl Steffen
, Heuer Heike
, Bruinstroop Eveline
, van der Spek Anne
, Boelen Anita
Innate immune cells, including macrophages, are functionally affected by thyroid hormone (TH). Macrophages can undergo phenotypical alterations, shifting between pro-inflammatory (M1) and anti-inflammatory (M2) profiles. Previous studies have established that increased TH concentrations shift macrophages into a more pro-inflammatory phenotype. Cellular TH concentrations are, in part, determined by TH transporters, cellular gateways facilitating bidirectional TH transport. An i...